Result : Based on this study, the ethanol extract of bandotan leaves at a dose of 126 mg / Kg BB, 252 mg / Kg, and 378 mg / Kg BB gave a decrease in blood sugar levels. The results were tested using the ANOVA method. Testing for antidiabetic effects was carried out on 15 male white rats divided into 5 treatment groups, namely the first group negative control (CMC Na 0.5%), the second group positive control (glibenclamide), the third group dose 126 mg / BB Kg, 4th group dose 252 mg / Kg BB, and group 5 dose 378 mg / Kg BB. The sample was extracted by maceration method using 70% ethanol sailor. Method : The method used is the experimental method. Purpose : To determine the effectiveness of bandotan leaf ethanol extract can reduce blood sugar levels compared to glibenclamide drugs. Therapies using synthetic drugs require a substantial amount of money and are having these side effects that encourage people to begin shifting into the traditional treatment of bandotan leaves. 8(4):267-9.Background : Diabetes mellitus is a metabolic disease with chronic characteristics of hyperglycemia with metabolic disorders of carb, fats, and proteins.
Xia, Z., Liang, J., 2010, Steroids and phenols from Sonchus arvensis. World Health Organization, 2011, Quality Control Methods for Herbal Materials. Triyono, A., 2016, Tujuh Ramuan Jamu Saintifik - Pemanfaatan Mandiri Oleh Masyarakat, Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan, Jakarta. Tapas, AR., Sakarkar, D., Kakde, R., 2008, Flavonoids as nutraceuticals: a review, Tropical Journal of Pharmaceutical Research, 7(3):1089-99. Seal, T., 2016, Quantitative HPLC analysis of phenolic acids, flavonoids and ascorbic acid in four different solvent extracts of two wild edible leaves, Sonchus arvensis and Oenanthe linearis of North-Eastern region in India, Journal of Applied Pharmaceutical Science, 6(2):157-66.
Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan, Jakarta. Purwadianto, A., Poerwaningsih, E., Widiyastuti, Y., Neilwan, A., Sukasediati, N., 2017, Pedoman Penelitian Jamu Berbasis Pelayanan Kesehatan. Menteri Kesehatan Republik Indonesia, Jakarta MENKES RI, 2013, Peraturan Menteri Kesehatan Republik Indonesia Nomor 82 Tahun 2013. MENKES/PER/2010 tentang saintifikasi jamu dalam penelitian berbasis pelayanan kesehatan. MENKES RI, 2010, Peraturan Menteri Kesehatan Republik Indonesia Nomor 003. Kumar, S., Pandey, AK., 2013, Chemistry and biological activities of flavonoids: an overview, The Scientific World Journal, 2013: 1-15 Krisyanella, K., Susilawati, N., Rivai, H., 2017, Pembuatan Dan Karakterisasi Serta Penentuan Kadar Flavonoid Dari Ekstrak Kering Herba Meniran (Phyllanthus niruri L.), Jurnal Farmasi Higea. Jayani, NIE., Kartini., Putri, LK., 2020, Standardization of a Crude Drug Moringa oleifera Leaf from Africa, India and Local (Indonesian) which Cultivated in Bojonegoro Indonesia, International Journal of Pharmaceutical Research. Departemen Kesehatan Republik Indonesia, Jakarta Departemen Kesehatan Republik Indonesia, JakartaĭEPKES RI, 2000, Parameter standar umum ekstrak tumbuhan obat. and their pharmacological properties: a review, Journal of Pharmacy and Pharmacology. 53(0):6-15.īagalkotkar, G., Sagineedu, S., Saad, M., Stanslas, J., 2006, Phytochemicals from Phyllanthus niruri Linn. The results showed that Phyllanthus niruri and Sonchus arvensis from the three places did not meet the standard requirement.Īmessis-Ouchemoukh, N., Madani, K., Falé, PLV., Serralheiro, ML., Araújo, MEM., 2014, Antioxidant capacity and phenolic contents of some Mediterranean medicinal plants and their potential role in the inhibition of cyclooxygenase-1 and acetylcholinesterase activities, Industrial Crops and Products. The methods of the determination referred to the Indonesian Herbal Pharmacopoeia 1 st Edition (2008). This study was aimed to determine the specific parameters (macroscopic, microscopic, total flavonoid content, water-soluble extract content, and ethanol-soluble extract content) and non-specific parameters (loss on drying, total ash content, and acid insoluble ash content) of Phyllanth us niruri and Sonch us arvensis collected from Batu, Tawangmangu, and Bogor. Components of the Scientific Jamu are standardized to ensure that these materials meet the predefined quality. Phyllanthus niruri and Sonchus arvensis are two of the 30 medicinal plants processed into Scientific Jamu.
Jamu has been empirically explored as a composition of various crude drugs, hence called as Scientific Jamu. Saintifikasi Jamu, or the scientific investigation of Jamu, is an evidence-based process to ensure the safety and efficacy of herbal medicine through health service research.